Trifluoroacetic acid → 4-Hydroxy-5-methoxy-7-iodoisoindolinone
반응식
COC[O:4][C:5]1[C:13]([O:14][CH3:15])=[CH:12][C:11]([I:16])=[C:10]2[C:6]=1[CH:7](O)[N:8](C(C)(C1C=CC=CC=1)C)[C:9]2=[O:17].FC(F)(F)C(O)=O.C([SiH](CC)CC)C>[N+](C)([O-])=O>[OH:4][C:5]1[C:13]([O:14][CH3:15])=[CH:12][C:11]([I:16])=[C:10]2[C:6]=1[CH2:7][NH:8][C:9]2=[O:17]참가 물질
5
실험 절차
In a similar manner to Step 4 of Example 16, 4-methoxymethoxy-5-methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (763 mg, 1.58 mmol) was dissolved in nitromethane (12 mL), and the solution was treated with trifluoroacetic acid (1.22 mL, 15.8 mmol) and triethylsilane (2.55 mL, 15.8 mmol), followed by purification by slurry using chloroform to obtain 4-hydroxy-5-methoxy-7-iodoisoindolinone (341 mg, yield 71%).
후처리
- customfollowed by purification by slurry
출처 및 근거
- ORD 기록
- ord-dca9ec98d00040359a79974573c43175
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07745641B2
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