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1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 3-methoxymethoxy-4-methyl-N-(1-methyl-1-phenylethyl)benzamide

HRID 21274
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HRID 21274 반응식
CCN=C=NCCCN(C)C.C1C=C2N=NN(O)C2=CC=1.O.[C:23]([NH2:32])([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)([CH3:25])[CH3:24].[CH3:33][O:34][CH2:35][O:36][C:37]1[CH:38]=[C:39]([CH:43]=[CH:44][C:45]=1[CH3:46])[C:40](O)=[O:41]>CN(C=O)C>[CH3:33][O:34][CH2:35][O:36][C:37]1[CH:38]=[C:39]([CH:43]=[CH:44][C:45]=1[CH3:46])[C:40]([NH:32][C:23]([CH3:25])([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH3:24])=[O:41]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 68509CumylamineHCID 27960291-Hydroxybenzotriazole hydrateHCID 596497153-(Methoxymethoxy)-4-methylbenzoic acid

생성물 1

HCID 684929793-methoxymethoxy-4-methyl-N-(1-methyl-1-phenylethyl)benzamide수율 83%

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

In a similar manner to Step 1 of Example 137, 3-methoxymethoxy-4-methylbenzoic acid (2.69 g) was dissolved in DMF (53 mL), and the solution was treated with EDCI (5.04 g, 26.3 mmol), HOBT monohydrate (2.01 g, 13.1 mmol) and cumylamine (3.80 mL, 26.4 mmol), followed by purification by slurry using hexane to obtain 3-methoxymethoxy-4-methyl-N-(1-methyl-1-phenylethyl)benzamide (3.42 g, yield 83%, 2 steps).

후처리

  1. customfollowed by purification by slurry

출처 및 근거

ORD 기록
ord-f2c8862367344837b0cf1963da893a4f
출처 데이터셋
uspto-grants-2010_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07745641B2

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