Triethylamine → 4-(3-Thiophenesulfonyloxy)-5-methoxy-7-iodoisoindolinone

HRID 21296

반응식

HRID 21296 반응식
[OH:1][C:2]1[C:10]([O:11][CH3:12])=[CH:9][C:8]([I:13])=[C:7]2[C:3]=1[CH2:4][NH:5][C:6]2=[O:14].C(N(CC)CC)C.[S:22]1[CH:26]=[CH:25][C:24]([S:27](Cl)(=[O:29])=[O:28])=[CH:23]1>C(#N)C>[S:22]1[CH:26]=[CH:25][C:24]([S:27]([O:1][C:2]2[C:10]([O:11][CH3:12])=[CH:9][C:8]([I:13])=[C:7]3[C:3]=2[CH2:4][NH:5][C:6]3=[O:14])(=[O:29])=[O:28])=[CH:23]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 2776378Thiophene-3-sulfonyl ChlorideHCID 684899574-Hydroxy-5-methoxy-7-iodoisoindolinone

생성물 1

HCID 866283134-(3-Thiophenesulfonyloxy)-5-methoxy-7-iodoisoindolinone수율 81%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

In a similar manner to Step 1 of Example 227, 4-hydroxy-5-methoxy-7-iodoisoindolinone (0.265 g, 0.869 mmol) was dissolved in acetonitrile (8.0 mL), and the solution was treated with triethylamine (0.242 mL, 1.74 mmol) and 3-thiophenesulfonyl chloride (0.191 g, 1.04 mmol) to obtain 4-(3-thiophenesulfonyloxy)-5-methoxy-7-iodoisoindolinone (0.316 g, yield 81%).

출처 및 근거

ORD 기록
ord-a8fb8bddf16f4efbacc49b7ec5486280
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745641B2

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