Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 4-Chloro-5-[4-(tert-butyldimethylsiloxy)butoxy]-7-iodoisoindolinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | tert-Butyl(4-iodobutoxy)dimethylsilane | HCID 4250746 | — |
| 반응물 | 4-Chloro-5-hydroxy-7-iodoisoindolinone | HCID 68489249 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Chloro-5-[4-(tert-butyldimethylsiloxy)butoxy]-7-iodoisoindolinone | HCID 68489186 | 84.1% |
반응 단계
In a similar manner to Step 1 of Example 429, 4-chloro-5-hydroxy-7-iodoisoindolinone (70.0 mg, 0.226 mmol) was dissolved in DMF (2.1 mL), and the solution was treated with potassium carbonate (93.8 mg, 0.679 mmol) and tert-butyl(4-iodobutoxy)dimethylsilane (0.176 mL, 0.679 mmol), followed by purification by flash column chromatography (chloroform/methanol=99/1, 19/1) to obtain 4-chloro-5-[4-(tert-butyldimethylsiloxy)butoxy]-7-iodoisoindolinone (94.2 mg, yield 84%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745641B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-b55de8f5f3794a9395126dbed7095092 |
| 출처 메모 | uspto-grants-2010_06 |