Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 4-Chloro-5-[3-methyl-3-(triethylsiloxy)butoxy]-7-iodoisoindolinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | (4-Bromo-2-methyl-2-butoxy)triethylsilane | HCID 11208288 | — |
| 반응물 | 4-Chloro-5-hydroxy-7-iodoisoindolinone | HCID 68489249 | — |
| 촉매 | Tetrabutylammonium Iodide | HCID 67553 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Chloro-5-[3-methyl-3-(triethylsiloxy)butoxy]-7-iodoisoindolinone | HCID 68490293 | 35% |
반응 단계
In a similar manner to Step 1 of Example 429, 4-chloro-5-hydroxy-7-iodoisoindolinone (70.8 mg, 0.229 mmol) was dissolved in DMF (2.1 mL), and the solution was treated with potassium carbonate (94.8 mg, 0.686 mmol), tetrabutylammonium iodide (8.5 mg, 0.023 mmol) and (4-bromo-2-methyl-2-butoxy)triethylsilane (193 mg, 0.686 mmol), followed by purification by flash column chromatography (chloroform/methanol=99/1) to obtain 4-chloro-5-[3-methyl-3-(triethylsiloxy)butoxy]-7-iodoisoindolinone (40.7 mg, yield 35%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745641B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-5a7c56d56b3b4a7793e205a9f0ed7e46 |
| 출처 메모 | uspto-grants-2010_06 |