Trifluoroacetic acid → 4-Bromo-1,2-dihydro-pyrrolo[3,4-c]pyridin-3-one

HRID 21339노트

반응식

HRID 21339 반응식
[Br:1][C:2]1[C:7]2[C:8](=[O:21])[N:9](C(C)(C3C=CC=CC=3)C)[CH:10](O)[C:6]=2[CH:5]=[CH:4][N:3]=1.FC(F)(F)C(O)=O.C([SiH](CC)CC)C>[N+](C)([O-])=O>[Br:1][C:2]1[C:7]2[C:8](=[O:21])[NH:9][CH2:10][C:6]=2[CH:5]=[CH:4][N:3]=1

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 86628337HCID 86628337, 화합물

생성물 1

HCID 768481334-Bromo-1,2-dihydro-pyrrolo[3,4-c]pyridin-3-one수율 34%

시약·촉매·용매 1

HCID 6375Nitromethane용매

실험 절차

In a similar manner to Step 4 of Example 16, 4-bromo-1-hydroxy-2-(1-methyl-1-phenylethyl)-1,2-dihydropyrrolo[3,4-c]pyridine-3-one (239 mg, 0.688 mmol) was dissolved in nitromethane (12 mL), and the solution was treated with trifluoroacetic acid (1.17 mL, 15.1 mmol) and triethylsilane (0.440 mL, 2.75 mmol), followed by purification by preparative thin-layer chromatography (chloroform/methanol=15/1) to obtain 4-bromo-1,2-dihydropyrrolo[3,4-c]pyridine-3-one (49.1 mg, yield 34%).

후처리

  1. customfollowed by purification by preparative thin-layer chromatography (chloroform/methanol=15/1)

출처 및 근거

ORD 기록
ord-1c154c18124c483081af4cb314070f73
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745641B2

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