Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 2,5-dichloro-N-(1-methyl-1-phenylethyl)nicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Cumylamine | HCID 68509 | — |
| 반응물 | 2,5-Dichloro-nicotinoyl chloride | HCID 2799996 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2,5-dichloro-N-(1-methyl-1-phenylethyl)nicotinamide | HCID 86628338 | 94% |
반응 단계
In a similar manner to Step 1 of Example 16, 2,5-dichloropyridine-3-carbonylchloride (669 mg, 3.19 mmol) was dissolved in dichloromethane (13 mL), and the solution was treated with cumylamine (0.505 mL, 3.51 mmol), triethylamine (0.667 mL, 4.79 mmol) and DMAP (39.0 mg, 0.319 mmol), followed by purification by slurry using diisopropylether/hexane to obtain 2,5-dichloro-N-(1-methyl-1-phenylethyl)nicotinamide (926 mg, yield 94%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745641B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-0164a6f54d57470083813ea7da61ae35 |
| 출처 메모 | uspto-grants-2010_06 |