Triethylamine → 2,5-dichloro-N-(1-methyl-1-phenylethyl)nicotinamide

HRID 21340

반응식

HRID 21340 반응식
[Cl:1][C:2]1[C:7]([C:8](Cl)=[O:9])=[CH:6][C:5]([Cl:11])=[CH:4][N:3]=1.[C:12]([NH2:21])([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([CH3:14])[CH3:13].C(N(CC)CC)C>ClCCl.CN(C1C=CN=CC=1)C>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([Cl:11])=[CH:6][C:7]=1[C:8]([NH:21][C:12]([CH3:14])([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH3:13])=[O:9]

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 68509CumylamineHCID 27999962,5-Dichloro-nicotinoyl chloride

생성물 1

HCID 866283382,5-dichloro-N-(1-methyl-1-phenylethyl)nicotinamide수율 94%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

In a similar manner to Step 1 of Example 16, 2,5-dichloropyridine-3-carbonylchloride (669 mg, 3.19 mmol) was dissolved in dichloromethane (13 mL), and the solution was treated with cumylamine (0.505 mL, 3.51 mmol), triethylamine (0.667 mL, 4.79 mmol) and DMAP (39.0 mg, 0.319 mmol), followed by purification by slurry using diisopropylether/hexane to obtain 2,5-dichloro-N-(1-methyl-1-phenylethyl)nicotinamide (926 mg, yield 94%).

후처리

  1. customfollowed by purification by slurry

출처 및 근거

ORD 기록
ord-0164a6f54d57470083813ea7da61ae35
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745641B2

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