1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 2-chloro-6-methyl-N-(1-methyl-1-phenylethyl)nicotinamide

HRID 21343노트

반응식

HRID 21343 반응식
[Cl:1][C:2]1[N:10]=[CH:9][C:8](C)=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:12]CN=C=NCCCN(C)C.C1C=C2N=NN(O)C2=CC=1.O.[C:34]([NH2:43])([C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)([CH3:36])[CH3:35]>CN(C=O)C.O>[Cl:1][C:2]1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7][C:3]=1[C:4]([NH:43][C:34]([CH3:36])([C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)[CH3:35])=[O:6]

참가 물질

7

반응물 4

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 68509CumylamineHCID 27960291-Hydroxybenzotriazole hydrateHCID 123877302-Chloro-5-methylnicotinic acid

생성물 1

HCID 866283402-chloro-6-methyl-N-(1-methyl-1-phenylethyl)nicotinamide수율 62%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

In a similar manner to Step 1 of Example 137, 2-chloro-5-methylnicotinic acid (2.00 g, 11.7 mmol) was dissolved in DMF (40 mL), and the solution was treated with EDCI (3.35 g, 17.5 mmol), HOBT monohydrate (890 mg, 5.83 mmol) and cumylamine (3.40 mL, 23.3 mmol). The mixture was added with water. The precipitated solid was collected by filtration and dried under reduced pressure to obtain 2-chloro-6-methyl-N-(1-methyl-1-phenylethyl)nicotinamide (2.09 mg, yield 62%).

후처리

  1. filtrationThe precipitated solid was collected by filtration
  2. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-9127249f319244ed9a3d3dc663bb9562
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745641B2

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