Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → N-(3-Cyano-4,5,6,7-tetrahydrobenzo(b)thien-2-yl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Benzoyl chloride | HCID 7412 | — |
| 반응물 | 2-Amino-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carbonitrile | HCID 78382 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | N-(3-Cyano-4,5,6,7-tetrahydrobenzo(b)thien-2-yl)benzamide | HCID 290221 | 97% |
반응 단계
4.7 ml (40 mmol) of benzoyl chloride were added to a solution of 5.34 g (30 mmol) of 2-amino-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene in 50 ml of pyridine. Stirring was carried out for 2 hours at 80° C. after which 150 ml of 10 mol % aqueous hydrochloric acid were added to the mixture. The solid formed was isolated in a conventional manner. Yield: 97%; mp.: 168°-170° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05422335 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-c687d545fb614a2799fe1a2c2fe90189 |
| 출처 메모 | uspto-grants-1995_06 |