Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 4-(Isopropoxymethyl)-pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | 4-(Chloromethyl)pyridinium chloride | HCID 74570 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 생성물 | 4-(Isopropoxymethyl)-pyridine | HCID 14442204 | — |
반응 단계
3.4 g of sodium are dissolved in 120 ml of isopropanol and 11 g (0.067 mol) of 4-chloromethylpyridine-hydrochloride are added. The reaction mixture is refluxed for 10 hours under nitrogen, with stirring, then after cooling it is made weakly acidic with dilute hydrochloric acid and concentrated by evaporation under reduced pressure. The residue is made alkaline with 40% potassium carbonate solution and extracted with ether. After drying with anhydrous sodium sulphate the organic phase is concentrated by evaporation. The crude product is then distilled.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05422353 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-9964c7de6933407d9c2220728e01fc8c |
| 출처 메모 | uspto-grants-1995_06 |