Dichloromethane → 3-(2-Thienyl)-propanoic acid chloride

HRID 21381

반응식

HRID 21381 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]([OH:10])=O.C(Cl)[Cl:12]>C(Cl)(=O)C(Cl)=O.CN(C)C=O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]([Cl:12])=[O:10]

참가 물질

5

반응물 2

HCID 6344DichloromethaneHCID 7031693-(2-Thienyl)propanoic acid

생성물 1

HCID 149601613-(2-Thienyl)-propanoic acid chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 65578Oxalyl chloride용매

실험 절차

To a solution of 5.0 g (0.032 mol) of 3-(2-thienyl)propionic acid in 2 ml of methylene chloride and 25 ml of oxalyl chloride was added three drops of N,N-dimethylformamide slowly. Following evolution of the gas the reaction mixture was concentrated under vacuum and 20 ml of hexane was added to the residue. The resulting mixture was filtered and the filtrate was concentrated under vacuum. The resulting compound, 3-(2-thienyl)propionyl chloride, was used directly in the following reaction.

후처리

  1. concentrationwas concentrated under vacuum and 20 ml of hexane
  2. additionwas added to the residue
  3. filtrationThe resulting mixture was filtered
  4. concentrationthe filtrate was concentrated under vacuum
  5. customThe resulting compound, 3-(2-thienyl)propionyl chloride, was used directly in the following reaction

출처 및 근거

ORD 기록
ord-ffccd1a407724a43aa8542a5d7381c8b
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05422356

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