Potassium Carbonate → 3-(R,S)-(1-carbamoyl-1,1-diphenylmetyl)-1-[3-(4-methoxyphenyl)propyl]piperidine

HRID 21395

반응식

HRID 21395 반응식
[C:1]([C:4]([CH:17]1[CH2:22][CH2:21][CH2:20][NH:19][CH2:18]1)([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)(=[O:3])[NH2:2].Br[CH2:24][CH2:25][CH2:26][C:27]1[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[C:1]([C:4]([CH:17]1[CH2:22][CH2:21][CH2:20][N:19]([CH2:24][CH2:25][CH2:26][C:27]2[CH:28]=[CH:29][C:30]([O:33][CH3:34])=[CH:31][CH:32]=2)[CH2:18]1)([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)(=[O:3])[NH2:2]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 127769961-(3-Bromopropyl)-4-methoxybenzeneHCID 136337483-(R,S)-(1-carbamoyl-1,1-diphenylmethyl)piperidine

생성물 1

HCID 212240993-(R,S)-(1-carbamoyl-1,1-diphenylmetyl)-1-[3-(4-methoxyphenyl)propyl]piperidine

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture containing 3-(R,S)-(1-carbamoyl-1,1-diphenylmethyl)piperidine (0.26 g), 1-bromo-3-(4-methoxyphenyl)propane (0.23 g), anhydrous potassium carbonate (0.3 g) and acetonitrile (10 ml) was heated under reflux for 16 hours. The mixture was partitioned between dichloromethane (30 ml) and 10% aqueous sodium carbonate (30 ml), the layers separated, and the aqueous layer extracted with dichloromethane (2×30 ml). The dichloromethane extracts were combined, dried (MgSO4) and concentrated in vacuo to give a solid which was recrystallised from ethanol to give the title compound, yield 0.19 g, m.p. 180°-182° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 16 hours
  3. customThe mixture was partitioned between dichloromethane (30 ml) and 10% aqueous sodium carbonate (30 ml)
  4. customthe layers separated
  5. extractionthe aqueous layer extracted with dichloromethane (2×30 ml)
  6. dry with materialdried (MgSO4)
  7. concentrationconcentrated in vacuo
  8. customto give a solid which
  9. customwas recrystallised from ethanol

출처 및 근거

ORD 기록
ord-2c0f66410bbd4d81851ffca9017a268d
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05422358

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