2,4-Dimethoxyphenyl isocyanate → 1-[4-(1,2-Dimethoxyethoxy)benzyl]-3-(2,4-dimethoxyphenyl)-1-heptylurea

HRID 21411

반응식

HRID 21411 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[N:11]=[C:12]=[O:13].[CH2:14]([NH:21][CH2:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH:30]([O:34][CH3:35])[CH2:31][O:32][CH3:33])=[CH:25][CH:24]=1)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]>C(#N)C>[CH3:35][O:34][CH:30]([O:29][C:26]1[CH:25]=[CH:24][C:23]([CH2:22][N:21]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:12]([NH:11][C:4]2[CH:5]=[CH:6][C:7]([O:9][CH3:10])=[CH:8][C:3]=2[O:2][CH3:1])=[O:13])=[CH:28][CH:27]=1)[CH2:31][O:32][CH3:33]

참가 물질

4

반응물 2

HCID 6016372,4-Dimethoxyphenyl isocyanateHCID 19934019N-n-Heptyl-4-(1,2-dimethoxyethoxy)benzylamine

생성물 1

HCID 98701161-[4-(1,2-Dimethoxyethoxy)benzyl]-3-(2,4-dimethoxyphenyl)-1-heptylurea수율 85.1%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

2,4-Dimethoxyphenyl isocyanate (Aldrich, 5.6 g) was added in one portion to a stirred solution of the product from step (c) (10.3 g) in acetonitrile (50 ml). The mixture was stood at room temperature for 2 days and then evaporated in vacuo to give a mobile pale tan oil which was flash chromatographed through a silica column using cyclohexane/ethyl acetate (1:1) as eluant to give the desired product as a colourless oil (13.0 g).

후처리

  1. customevaporated in vacuo
  2. customto give a mobile pale tan oil which
  3. customchromatographed through a silica column

출처 및 근거

ORD 기록
ord-a2108f40fc02470892b97b6f36e35dca
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05422373

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