(R)-(+)-1,1,1-trifluoro-2-octyl 4-benzyloxybenzoate → 4-hydroxybenzoic acid (R)-1-trifluoromethyl-heptyl ester

HRID 21428

반응식

HRID 21428 반응식
C([O:8][C:9]1[CH:28]=[CH:27][C:12]([C:13]([O:15][C@H:16]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:17]([F:20])([F:19])[F:18])=[O:14])=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]([O:15][C@H:16]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:17]([F:18])([F:19])[F:20])=[O:14])=[CH:27][CH:28]=1

참가 물질

5

반응물 2

HCID 22850730(R)-(+)-1,1,1-trifluoro-2-octyl 4-benzyloxybenzoateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 145492174-hydroxybenzoic acid (R)-1-trifluoromethyl-heptyl ester

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of the compound obtained in (1) above (3.8 g) in methanol (100 ml), was added 10% Pd on carbon (0.4 g). The mixture was subjected to hydrogenation in an atmosphere of hydrogen to obtain the titled compound (2.8 g).

출처 및 근거

ORD 기록
ord-fbe288e2989d4a03b569285ac19ab96c
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05424005

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