Methylparaben → Methyl 4-(octadecyloxy)benzoate

HRID 21433

반응식

HRID 21433 반응식
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][CH:3]=1.[CH2:12](Br)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[CH2:29]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:10][CH:11]=1)[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH3:12]

참가 물질

5

반응물 3

HCID 7456MethylparabenHCID 82181-BromooctadecaneHCID 11430Potassium Carbonate

생성물 1

HCID 4189536Methyl 4-(octadecyloxy)benzoate수율 45.4%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

A mixture containing methyl 4-hydroxybenzoate (45.6 g), octadecylbromide (100 g), and potassium carbonate (41.4 g) in 2-butanone (200 ml) was heated at reflux for 16 hours. The solvent was then removed until 125 ml of 2-butanone had been collected. While it was still warm, the remaining material was poured into methanol (400 ml). The product was filtered and recrystallized from 2000 ml of methanol to give methyl 4-octadecyloxybenzoate (55 g).

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 16 hours
  3. customThe solvent was then removed until 125 ml of 2-butanone
  4. customhad been collected
  5. temperatureWhile it was still warm
  6. additionthe remaining material was poured into methanol (400 ml)
  7. filtrationThe product was filtered
  8. customrecrystallized from 2000 ml of methanol

출처 및 근거

ORD 기록
ord-5bd9025ada774765b81d784d3b0ccf52
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05424183

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