2-Fluoro-4-chloro-5-cyclopentyloxynitrobenzene → 4-Chloro-5-(cyclopentyloxy)-2-fluorobenzenamine

HRID 21475

반응식

HRID 21475 반응식
[F:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][CH:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:4][C:3]=1[N+:15]([O-])=O>C1(C)C=CC=CC=1.[C].[Pd]>[F:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][CH:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:4][C:3]=1[NH2:15]

참가 물질

4

반응물 1

HCID 193744702-Fluoro-4-chloro-5-cyclopentyloxynitrobenzene

생성물 1

HCID 152793894-Chloro-5-(cyclopentyloxy)-2-fluorobenzenamine

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 1140Toluene용매

실험 절차

The resulting 2-fluoro-4-chloro-5-cyclopentyloxynitrobenzene (13.0 g, 50.1 mmol) was dissolved in toluene (100 ml), a catalytic amount of 10% palladium-carbon (0.5 g) was added thereto, and the mixture was reacted at room temperature to 70° C. under a hydrogen pressure of 3 to 5 atms. in a glass autoclave. After absorption of hydrogen gas ceased, the catalyst was removed by filtration, and the solvent was distilled off under reduced pressure from the filtrate to obtain substantially quantitatively oily 2-fluoro-4-chloro-5-cyclopentyloxyaniline. The spectral data and the like are as described in Reference Example 1.

후처리

  1. customthe mixture was reacted at room temperature to 70° C. under a hydrogen pressure of 3 to 5 atms
  2. customAfter absorption of hydrogen gas
  3. customthe catalyst was removed by filtration
  4. distillationthe solvent was distilled off under reduced pressure from the filtrate

출처 및 근거

ORD 기록
ord-67f78207c5b64f1ab0a8cb7a7aad0bee
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05424277

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