4-(3-Methyl-1H-1,2,4-triazol-1-yl)aniline → (R)-4-Methyl-N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine

참여 물질

역할	이름	HCID	투입량
반응물	4-(3-Methyl-1H-1,2,4-triazol-1-yl)aniline	HCID 44627476	—
반응물	(2R)-8-chloro-4-methyl-2-phenyl-3,5-dihydro-2H-pyrido[3,2-f][1,4]oxazepine	HCID 57512880	—
시약	Cesium carbonate	HCID 10796	—
촉매	1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)	HCID 636044	—
촉매	Palladium (II) acetate	HCID 4144353	—
용매	1,2-Dimethoxyethane	HCID 8071	—
생성물	(R)-4-Methyl-N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine	HCID 49819370	0%

반응 조건

온도	100 °C

반응 단계

A solution of (R)-8-chloro-4-methyl-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine (5.00 mg, 0.02 mmol) and 4-(3-methyl-1H-1,2,4-triazol-1-yl)aniline (3.17 mg, 0.02 mmol) in DME (.5 mL) was added via a syringe to a capped microwave vial containing PALLADIUM(II) ACETATE (0.409 mg, 1.82 µmol), XANTPHOS (1.053 mg, 1.82 µmol) and CESIUM CARBONATE (8.89 mg, 0.03 mmol) under an argon atmosphere. The resulting mixture was heated to 100°C in a microwavwe apparatus for 1 h and analyzed by LCMS. No product.

출처 및 근거

출처 데이터셋	750 AstraZeneca ELN dataset
ORD ID	ord-221a1c88a71944db90ec733265031251
출처 메모	750 AstraZeneca ELN dataset