Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1-(2-Chloropyridin-4-yl)ethan-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | 2-Chloro-4-cyanopyridine | HCID 568638 | — |
| 반응물 | HCID 178418332 | HCID 178418332 | — |
| 생성물 | 1-(2-Chloropyridin-4-yl)ethan-1-one | HCID 13145255 | — |
반응 단계
24.61 g (177.62 mmol) of 2-chloro-4-cyano-pyridine are placed in 1.25 litres of diethyl ether under nitrogen, and 120 ml (22% in tetrahydrofuran, 353 mmol) of methyl-magnesium chloride are added. The red suspension is stirred for 40 h at RT, poured onto 1.25 litres of ice/water and 250 ml of 6N HCl and stirred for 14 h at RT. Extraction with diethyl ether and methylene chloride, drying with MgSO4 and concentration give 4-acetyl-2-chloro-pyridine; Rf =0.5 (methylene chloride:methanol=9:1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05728708 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-160c9a75cc8c48d189fa78e2f7af0bda |
| 출처 메모 | uspto-grants-1998_03 |