3-Methylpyrido(3,4-b)pyrazin-2(1H)-one → HCID 53669727, 화합물

HRID 21527노트

반응식

HRID 21527 반응식
[CH3:1][C:2]1[C:3](=[O:12])[NH:4][C:5]2[C:10]([N:11]=1)=[CH:9][N:8]=[CH:7][CH:6]=2.[H][H]>CO.[Pd].[Pd].[C]>[CH3:1][CH:2]1[NH:11][C:10]2[C:5](=[CH:6][CH:7]=[N:8][CH:9]=2)[NH:4][C:3]1=[O:12]

참가 물질

6

반응물 2

HCID 217791363-Methylpyrido(3,4-b)pyrazin-2(1H)-oneHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 53669727HCID 53669727, 화합물수율 82%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

3-Methyl-1,4,6-triazanaphthalen-2(1H)-one (J. W. Clark-Lewis, R. P. Singh J. Chem. Soc. 1962, 3162) (3.1 g, 0.02 mol) was hydrogenated in 300 ml of methanol with palladium catalysis (10% Pd/carbon) under 1 atm of hydrogen. After hydrogen uptake ceased, the catalyst was filtered off with suction, the solvent was removed, and the residue was stirred with diethyl ether and filtered off with suction. 2.6 g (82%) of the desired product of melting point 230° C. (dec.) were obtained.

후처리

  1. filtrationthe catalyst was filtered off with suction
  2. customthe solvent was removed
  3. filtrationfiltered off with suction

출처 및 근거

ORD 기록
ord-b566065b42fe4b3faa3ce20642721aa8
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05424311

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