Methanol → 4-(2-Chloro-3,6-difluoro-phenoxy)-6-[6-(4-methylpiperazin-1-yl)-pyridin-3-yl]-1,2,3,4-tetrahydro-[1,8]naphthyridine

반응식

[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([c:8]2[cH:9][cH:10][c:11](-[c:14]3[cH:15][c:16]4[c:21]([n:22][cH:23]3)[NH:20][CH2:19][CH2:18][CH:17]4[OH:24])[cH:12][n:13]2)[CH2:6][CH2:7]1.[CH3:35][OH:36].[Cl:25][c:26]1[c:27]([OH:34])[c:28]([F:33])[cH:29][cH:30][c:31]1[F:32].[Cl:37][CH2:38][Cl:39]>>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([c:8]2[cH:9][cH:10][c:11](-[c:14]3[cH:15][c:16]4[c:21]([n:22][cH:23]3)[NH:20][CH2:19][CH2:18][CH:17]4[O:24][c:27]3[c:26]([Cl:25])[c:31]([F:32])[cH:30][cH:29][c:28]3[F:33])[cH:12][n:13]2)[CH2:6][CH2:7]1