Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isopropenyl chloroformate → (2RS)-1-(Isopropenyloxycarbonyl)-2-methyl-1,2-dihydro-1,4,6-triazanaphthalen-3(4H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isopropenyl chloroformate | HCID 93846 | — |
| 반응물 | 2-methyl-1H,2H,3H,4H-pyrido[3,4-b]pyrazin-3-one | HCID 19932881 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | (2RS)-1-(Isopropenyloxycarbonyl)-2-methyl-1,2-dihydro-1,4,6-triazanaphthalen-3(4H)-one | HCID 19932849 | 12% |
반응 단계
(2RS)-2-Methyl-1,2-dihydro-1,4,6-triazanaphthalen-3(4H)-one (A. Albert, G. B. Barlin J. Chem. Soc. 1963, 5156) (570 mg, 3.5 mmol) was dissolved in 30 ml of anhydrous pyridine and cooled in an ice bath. 0.42 ml (3.8 mmol) of isopropenyl chloroformate was added dropwise, and the mixture was subsequently stirred at room temperature overnight. Concentration, chromatography on silica gel (ethyl acetate/methanol=20:1) and crystallization (pentane/diethyl ether) resulted in 100 mg (12%) of the desired product of melting point 170°-171° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05424311 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-51bf8dc81a7448649807c64ccbba7baf |
| 출처 메모 | uspto-grants-1995_06 |