Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloro-3-nitropyridine → N-(3-nitro-2-pyridyl)-(-)-S-methyl-L-cysteine methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloro-3-nitropyridine | HCID 79613 | — |
| 반응물 | Methyl (2R)-2-amino-3-(methylsulfanyl)propanoate | HCID 1277655 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | N-(3-nitro-2-pyridyl)-(-)-S-methyl-L-cysteine methyl ester | HCID 22853894 | 54.1% |
반응 단계
In analogy to Example 2, but using only one mole equivalent of triethylamine, 5 g (27 mmol) of (-)-S-methyl-L-cysteine methyl ester were reacted with 3.51 g (22.5 mmol) of 2-chloro-3-nitropyridine (reaction conditions: 5 hours at 80° C.). Working up was followed by chromatography on silica gel (n-heptane/acetone/methyl t-butyl ether=5:1:1). 3.3 g (45%) of N-(3-nitro-2-pyridyl)-(-)-S-methyl-L-cysteine methyl ester, of melting point 95°-97° C., were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05424311 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-68f2246ec70343a2bb4deaa94940cc63 |
| 출처 메모 | uspto-grants-1995_06 |