Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3(R,S)-Phenyl-3,4-dihydro-1,4,5-triazanaphthalen-2(1H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Chloro-3-nitropyridine | HCID 79613 | — |
| 반응물 | Methyl phenylglycinate, L- | HCID 1201451 | — |
| 용매 | n-Heptane acetone methyl t-butyl ether | HCID 131719020 | — |
| 생성물 | 3(R,S)-Phenyl-3,4-dihydro-1,4,5-triazanaphthalen-2(1H)-one | HCID 12238423 | — |
반응 단계
In analogy to Example 2, but using only one mole equivalent of triethylamine, 4.45 g (27 mmol) of D/L-phenylglycine methyl ester were reacted with 3.51 g (22 mmol) of 2-chloro-3-nitropyridine. Working up and column chromatography (n-heptane/acetone/methyl t-butyl ether=5:1:1) resulted in 3.27 g (42%) of N-(3-nitro-2-pyridyl)-(D/L)-phenylglycine methyl ester of melting point 70° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05424311 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-f34fac4c8ee24d50b5e8661561835b8e |
| 출처 메모 | uspto-grants-1995_06 |