2,6-Dimethyl-4-pyranone → Tetrahydro-2,6-dimethyl-4H-pyran-4-one

HRID 21561

반응식

HRID 21561 반응식
[CH3:1][C:2]1[O:8][C:7]([CH3:9])=[CH:6][C:4](=[O:5])[CH:3]=1>CCO>[CH3:9][CH:7]1[CH2:6][C:4](=[O:5])[CH2:3][CH:2]([CH3:1])[O:8]1

참가 물질

3

반응물 1

HCID 138622,6-Dimethyl-4-pyranone

생성물 1

HCID 70626Tetrahydro-2,6-dimethyl-4H-pyran-4-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 2,6-dimethyl-γ-pyrone (17 g, Aldrich) in EtOH 95% (300 mL) was hydrogenated for 3 days under 70 psi. After filtration over celite, the solvent was evaporated and replaced by CH2Cl2. The solution was then treated with celite (30 g) and PCC (48.5 g). The suspension was stirred for 3 hr. and the reaction was diluted with Et2O (300 mL) and then filtered over a pad of celite. The filtrate was evaporated to dryness and the residual solution was then chromatographed using hexane/Et2O (1:1) to give the title compound.

후처리

  1. filtrationAfter filtration over celite
  2. customthe solvent was evaporated
  3. additionThe solution was then treated with celite (30 g) and PCC (48.5 g)
  4. additionand the reaction was diluted with Et2O (300 mL)
  5. filtrationfiltered over a pad of celite
  6. customThe filtrate was evaporated to dryness
  7. customthe residual solution was then chromatographed

출처 및 근거

ORD 기록
ord-5f26eb2c965e46b1b3e67610bca06f60
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05424320

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