참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Butyric Acid | HCID 264 | — |
| 반응물 | Resorcinol | HCID 5054 | — |
| 반응물 | Hydrochloric acid brine | HCID 131718760 | — |
| 촉매 | Zincchloride | HCID 3007855 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | 4-Butanoylresorcinol | HCID 78103 | — |
반응 단계
To a solution of resorcinol (1.5 g) and butyric acid (2.9 mL) in 1,2-dichloroethane (45 mL) was added ZnCl2 (3.22 g) and the mixture then heated at 150° C. under nitrogen for 5 hr. The reaction mixture was cooled, poured onto 1N HCl/brine and extracted (3×EtOAc). After washing with 0.1N K2CO3, then twice with brine, the organic layer was dried and evaporated. Chromatography of the residue (silica gel; hexane/EtOAc 2:1) afforded the title product as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05424320 |
|---|
| 출처 데이터셋 | uspto-grants-1995_06 |
|---|
| ORD ID | ord-5feac7a055d54d6b800611b7f2f7387e |
|---|
| 출처 메모 | uspto-grants-1995_06 |
|---|
