2-Chloroethyl Isothiocyanate → HCID 68954103, 화합물

HRID 215708

반응식

HRID 215708 반응식
[Cl:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][NH2:5].Cl[CH2:12][CH2:13][N:14]=[C:15]=[S:16]>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][NH:5][C:15]1[S:16][CH2:12][CH2:13][N:14]=1

참가 물질

4

반응물 2

HCID 1386612-Chloroethyl IsothiocyanateHCID 5876252,3-Dichlorobenzylamine

생성물 1

HCID 68954103HCID 68954103, 화합물수율 163.2%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
80 °C

실험 절차

A mixture of 0.5 gram (0.0028 mole) of 2,3-dichlorobenzylamine and 0.27 gram (0.0081 mole) of 2-chloroethylisothiocyanate in 10 mL of 1,4-dioxane was placed in a sealed reaction vial. The reaction mixture was heated to 80° C. where it stirred for about 18 hours. The reaction mixture was allowed to cool and a solid precipitate that had formed was collected by filtration. The solid was rinsed with diethyl ether and was dried under reduced pressure to yield 0.68 gram of the title compound. The NMR spectrum was consistent with the proposed structure.

후처리

  1. customwas placed in a sealed reaction vial
  2. temperatureto cool
  3. customa solid precipitate that had formed
  4. filtrationwas collected by filtration
  5. washThe solid was rinsed with diethyl ether
  6. customwas dried under reduced pressure

출처 및 근거

ORD 기록
ord-6d25758682194a3e9cb055f2726f3e52
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193118B2

연결된 노트

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