참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Resorcinol | HCID 5054 | — |
| 반응물 | Ethyl benzoylacetate | HCID 7170 | — |
| 용매 | Phosphoric Acid | HCID 1004 | — |
| 생성물 | 7-Hydroxy-4-phenylcoumarin | HCID 5357479 | — |
반응 단계
A mixture of resorcinol (20 g), ethyl benzoylacetate (23.8 mL) and O-phosphoric acid (130 mL) was heated at 85° C. (care!) for 1 hr. The solution was cooled, poured onto H2O, extracted 3×EtOAc/THF, washed twice with H2O, and then twice with brine. The organic phase was dried and evaporated. Trituration with Et2O followed by filtration afforded the title compound as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05424320 |
|---|
| 출처 데이터셋 | uspto-grants-1995_06 |
|---|
| ORD ID | ord-676f55a760bb46bcbae02c9496dfc607 |
|---|
| 출처 메모 | uspto-grants-1995_06 |
|---|
