2-Chloroethyl Isothiocyanate → ((2,3-Dimethylphenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride

HRID 215710

반응식

HRID 215710 반응식
[CH3:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][NH2:5].[Cl:11][CH2:12][CH2:13][N:14]=[C:15]=[S:16]>O1CCOCC1>[ClH:11].[CH3:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][NH:5][C:15]1[S:16][CH2:12][CH2:13][N:14]=1

참가 물질

4

반응물 2

HCID 1386612-Chloroethyl IsothiocyanateHCID 2800811(2,3-Dimethylphenyl)methanamine

생성물 1

HCID 68955163((2,3-Dimethylphenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride수율 76%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
80 °C

실험 절차

Under a dry nitrogen atmosphere, a stirred mixture of 5.56 grams (0.041 mole) of 2,3-dimethylbenzylamine and 5.0 grams (0.041 mole) of 2-chloroethylisothiocyanate in 100 mL of 1,4-dioxane was heated to 80° C. where it stirred for about 18 hours. The reaction mixture was allowed to cool and a solid precipitate that had formed was collected by filtration. The solid was rinsed with diethyl ether and was dried under reduced pressure to yield 8.0 grams of the title compound. The NMR spectrum was consistent with the proposed structure.

후처리

  1. temperatureto cool
  2. customa solid precipitate that had formed
  3. filtrationwas collected by filtration
  4. washThe solid was rinsed with diethyl ether
  5. customwas dried under reduced pressure

출처 및 근거

ORD 기록
ord-ab661d7a8bcc4d6ba081a13baa6c3320
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193118B2

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