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m-Chloroperbenzoic acid → 3-[2-Methoxy-3-(methylsulfinyl)-4-(trifluoro-methyl)benzoyloxy]cyclohex-2-en-1-one

HRID 215719
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HRID 215719 반응식
ClC1C=CC=C(C(OO)=[O:9])C=1.[CH3:12][O:13][C:14]1[C:29]([S:30][CH3:31])=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=[CH:26][C:15]=1[C:16]([O:18][C:19]1[CH2:24][CH2:23][CH2:22][C:21](=[O:25])[CH:20]=1)=[O:17].S([O-])(O)=O.[Na+]>ClCCl>[CH3:12][O:13][C:14]1[C:29]([S:30]([CH3:31])=[O:9])=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=[CH:26][C:15]=1[C:16]([O:18][C:19]1[CH2:24][CH2:23][CH2:22][C:21](=[O:25])[CH:20]=1)=[O:17]
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참가 물질

5

반응물 3

HCID 70297m-Chloroperbenzoic acidHCID 23665763Sodium BisulfiteHCID 669579063-(2-Methoxy-3-methylthio-4-(trifluoromethyl)benzoyloxy)-cyclohex-2-enone

생성물 1

HCID 669579183-[2-Methoxy-3-(methylsulfinyl)-4-(trifluoro-methyl)benzoyloxy]cyclohex-2-en-1-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

68 mg (70% by weight, 0.28 mmol) of meta-chloroperbenzoic acid were added to 100 mg (0.28 mmol) of 3-(2-methoxy-3-methylthio-4-(trifluoromethyl)benzoyloxy)-cyclohex-2-enone in 10 ml of dichloromethane. The mixture was stirred at RT for 1 h. For work-up, 3 ml of 10 percent strength aqueous sodium hydrogensulfite solution were added. After confirmation that no peroxides were present, the organic phase was washed twice with in each case 5 ml of saturated aqueous NaHCO3 solution. After phase separation, the solvent was removed. This gave 90 mg of 3-(2-methoxy-3-methylsulfinyl-4-(trifluoromethyl)benzoyloxy)cyclohex-2-enone.

후처리

  1. washthe organic phase was washed twice with in each case 5 ml of saturated aqueous NaHCO3 solution
  2. customAfter phase separation
  3. customthe solvent was removed

출처 및 근거

ORD 기록
ord-2aea83e576b046a68fdb4f0fd17ae248
출처 데이터셋
uspto-grants-2012_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08193121B2

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