1-Bromohexadecane → 4-amino-1-[[(5S)-2-hexadecoxy-2-oxo-1,4,2$l^{5}-dioxaphosphinan-5-yl]methyl]pyrimidin-2-one

반응식

Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[CH2:18]1[O:24][P:22]([OH:25])(=[O:23])[CH2:21][O:20][C@H:19]1[CH2:26][N:27]1[C:32](=[O:33])[N:31]=[C:30]([NH2:34])[CH:29]=[CH:28]1>>[CH3:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][O:25][P:22]1([O:24][CH2:18][C@H:19]([CH2:26][N:27]2[C:32](=[O:33])[N:31]=[C:30]([NH2:34])[CH:29]=[CH:28]2)[O:20][CH2:21]1)=[O:23]

참가 물질

반응물 2

HCID 82131-Bromohexadecane

HCID 122873Cyclic HPMPC

생성물 1

HCID 4834724-amino-1-[[(5S)-2-hexadecoxy-2-oxo-1,4,2$l^{5}-dioxaphosphinan-5-yl]methyl]pyrimidin-2-one수율 55%

실험 절차

The title compound was prepared using the same procedure as described for Example 1 using 1-bromohexadecane and cyclic cidofovir.

출처 및 근거

ORD 기록: ord-6abf863f88864c4eae7650480f24dadc
출처 데이터셋: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08193167B2

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