Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Carbon Tetrachloride → 7-Chloromethyl-4-(3-thienyl)coumarin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Carbon Tetrachloride | HCID 5943 | — |
| 반응물 | Hexamethylphosphorous triamide | HCID 15355 | — |
| 반응물 | 7-Hydroxymethyl-4-(3-thienyl)coumarin | HCID 15780558 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 7-Chloromethyl-4-(3-thienyl)coumarin | HCID 15780559 | — |
반응 단계
To a solution of the alcohol from Step 1 (1.65 g) and hexamethylphosphorous triamide in 35 mL THF at 0° C. was added CCl4 (1.3 mL) and the mixture stirred for 30 min. The mixture was diluted with Et2O, filtered, concentrated and the residue chromatographed (30% EtOAc/hexane) to provide the title compound as a solid, m.p. 125°-127° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05424320 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-41bf4b14ae7e4194a8b652aa27b29dc4 |
| 출처 메모 | uspto-grants-1995_06 |