2-(Trifluoromethyl)benzenepropanoic acid → 5,7-Dichloro-1'-(3-(2-(trifluoromethyl)phenyl)propanoyl)spiro[isoindoline-1,4'-piperidin]-3-one

반응식

[Cl:16][c:17]1[cH:18][c:19]2[c:23]([c:24]([Cl:26])[cH:25]1)[C:22]1([NH:21][C:20]2=[O:32])[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]1.[F:1][C:2]([c:3]1[c:4]([CH2:9][CH2:10][C:11](=[O:12])[OH:13])[cH:5][cH:6][cH:7][cH:8]1)([F:14])[F:15]>>[F:1][C:2]([c:3]1[c:4]([CH2:9][CH2:10][C:11](=[O:13])[N:29]2[CH2:28][CH2:27][C:22]3([NH:21][C:20](=[O:32])[c:19]4[cH:18][c:17]([Cl:16])[cH:25][c:24]([Cl:26])[c:23]43)[CH2:31][CH2:30]2)[cH:5][cH:6][cH:7][cH:8]1)([F:14])[F:15]

참가 물질

반응물 2

HCID 152848092-(Trifluoromethyl)benzenepropanoic acid

HCID 582957645,7-Dichlorospiro[isoindoline-1,4'-piperidin]-3-one

생성물 1

HCID 582957305,7-Dichloro-1'-(3-(2-(trifluoromethyl)phenyl)propanoyl)spiro[isoindoline-1,4'-piperidin]-3-one

출처 및 근거

ORD 기록: ord-cc57df05d679494e9b2e9d7c6e63b490
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

반응 노트

불러오는 중…