4-(N-Boc-amino)piperidine → (4-Amino-piperidin-1-yl)-((R)-3-amino-pyrrolidin-1-yl)-methanone

반응식

N[CH:2]1[CH2:7]C[CH:5]([NH:8][C:9]([N:11]2[CH2:15][CH2:14][C@@H:13]([NH2:16])[CH2:12]2)=[O:10])[CH2:4][CH2:3]1.C(OC(=O)[NH:23]C1CCNCC1)(C)(C)C>>[NH2:23][CH:3]1[CH2:2][CH2:7][N:8]([C:9]([N:11]2[CH2:15][CH2:14][C@@H:13]([NH2:16])[CH2:12]2)=[O:10])[CH2:5][CH2:4]1

참가 물질

반응물 2

HCID 7238334-(N-Boc-amino)piperidine

HCID 67022910(R)-3-Amino-pyrrolidine-1-carboxylic acid (4-amino-cyclohexyl)-amide

생성물 1

HCID 67022950(4-Amino-piperidin-1-yl)-((R)-3-amino-pyrrolidin-1-yl)-methanone

실험 절차

(4-Amino-piperidin-1-yl)-((R)-3-amino-pyrrolidin-1-yl)-methanone is prepared analogously to (R)-3-amino-pyrrolidine-1-carboxylic acid (4-amino-cyclohexyl)-amide (Intermediate IF) by replacing (4-amino-cyclohexyl)-carbamic acid tert-butyl ester with piperidin-4-yl-carbamic acid tert-butyl ester.

출처 및 근거

ORD 기록: ord-ef73d520d4824a128627fa3b04cf99cd
출처 데이터셋: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08193164B2

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