Dichloromethane → benzyl 4-[4-amino-3-(4-amino-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylate

HRID 2159149

반응식

HRID 2159149 반응식
[Cl:50][CH2:51][Cl:52].[NH2:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[n:8]([CH:27]1[CH2:28][CH2:29][N:30]([C:33](=[O:34])[O:35][CH2:36][c:37]3[cH:38][cH:39][cH:40][cH:41][cH:42]3)[CH2:31][CH2:32]1)[n:9][c:10]2-[c:11]1[cH:12][c:13]([O:25][CH3:26])[c:14]([NH:17][C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[cH:15][cH:16]1.[OH:43][C:44]([C:45]([F:46])([F:47])[F:48])=[O:49]>>[NH2:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[n:8]([CH:27]1[CH2:28][CH2:29][N:30]([C:33](=[O:34])[O:35][CH2:36][c:37]3[cH:38][cH:39][cH:40][cH:41][cH:42]3)[CH2:31][CH2:32]1)[n:9][c:10]2-[c:11]1[cH:12][c:13]([O:25][CH3:26])[c:14]([NH2:17])[cH:15][cH:16]1

참가 물질

4

반응물 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 22346687benzyl 4-(4-amino-3-{4-[(tert-butoxycarbonyl)amino]-3-methoxyphenyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-piperidinecarboxylate

생성물 1

HCID 22346984benzyl 4-[4-amino-3-(4-amino-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylate

출처 및 근거

ORD 기록
ord-6259b64cfe0644459fad2148338d0235
출처 데이터셋
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

연결된 노트

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