Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 215915생성일: 2026년 10월 25일
Diethyl (3-aminopropyl)phosphonate → Diethyl 3-(4-(1-(2-(Dimethylamino)-6-methoxybenzyl)piperidin-4-ylamino)quinazolin-2-ylamino)propylphosphonate
https://huagongshe.com/reaction/215915
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diethyl (3-aminopropyl)phosphonate | HCID 78113 | — |
| 반응물 | 2-Chloro-N-(1-(2-(dimethylamino)-6-methoxybenzyl)piperidin-4-yl)quinazolin-4-amine | HCID 58006255 | — |
| 용매 | 1-Butanol | HCID 263 | — |
| 생성물 | Diethyl 3-(4-(1-(2-(Dimethylamino)-6-methoxybenzyl)piperidin-4-ylamino)quinazolin-2-ylamino)propylphosphonate | HCID 58006204 | — |
반응 단계
Following General Procedure D, Compound 47 (50 mg, 0.12 mmol) and diethyl 3-aminopropylphosphonate (69 mg, 0.36 mmol) in n-BuOH (3 mL) were heated to 117° C. for 24 h with a reflux condenser. The product (Compound 81) was purified by preparative silica gel TLC plate 1000μ using 5% (7N NH3-MeOH) and 95% CH2Cl2 solution as eluent.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08193203B2 |
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| 출처 데이터셋 | uspto-grants-2012_06 |
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| ORD ID | ord-ce4843057c1b49bcb9d1098f304d04c1 |
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| 출처 메모 | uspto-grants-2012_06 |
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