Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 3-(Diethylamino)-5-methoxy-1H-indole-2-carboxamide, monohydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Lithium amide | HCID 24532 | — |
| 반응물 | ethyl 3-(diethylamino)-5-methoxy-1H-indole-2-carboxylate | HCID 13837937 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 3-(Diethylamino)-5-methoxy-1H-indole-2-carboxamide, monohydrochloride | HCID 131719022 | 36% |
반응 단계
Prepared from ethyl 3-(diethylamino)-5-methoxy-1H-indole-2-carboxylate (Unangst PC, et al., J. Heterocyclic Chem. 1987;24:817) and lithium amide by the procedure described in Example 18, with the exception that dilute acetic acid is substituted for 1.0N HCl during the wash of the ethyl acetate extracts. The crude product is purified by flash chromatography (silica gel, 30% ethyl acetate in dichloromethane elution) to give a foam. The foam is dissolved in ether and treated with gaseous HCl to provide the product salt in 36% yield after recrystallization from acetonitrile; mp 244° C.-dec.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05424329 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-37fa8988fca1478b905c4ec599fe19b5 |
| 출처 메모 | uspto-grants-1995_06 |