Isopropyl iodide → 3-Isopropoxy-N,N-dimethylaniline

HRID 215928

반응식

HRID 215928 반응식
[CH3:1][N:2]([CH3:10])[C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.C([O-])([O-])=O.[K+].[K+].I[CH:18]([CH3:20])[CH3:19]>CC(C)=O>[CH:18]([O:9][C:5]1[CH:4]=[C:3]([CH:8]=[CH:7][CH:6]=1)[N:2]([CH3:10])[CH3:1])([CH3:20])[CH3:19]

참가 물질

5

반응물 3

HCID 6362Isopropyl iodideHCID 74213-(Dimethylamino)phenolHCID 11430Potassium Carbonate

생성물 1

HCID 580062633-Isopropoxy-N,N-dimethylaniline

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 3-(dimethylamino)phenol (2.0 g, 14.60 mmol) in acetone (40.0 mL) were added K2CO3 (20.2 g, 146.0 mmol) and 2-iodopropane (2.20 mL, 21.90 mmol), and the reaction was refluxed for 18 h, then cooled to room temperature, and filtered through Celite. The solvent was removed under vacuum, and the residue was purified by silica gel chromatography using ethyl acetate (20%) and hexanes (80%) as eluent to produce Compound 135 as yellow oil.

후처리

  1. temperaturethe reaction was refluxed for 18 h
  2. filtrationfiltered through Celite
  3. customThe solvent was removed under vacuum
  4. customthe residue was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-56a13a33a481464abc3dc54c25c3545e
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193203B2

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