Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium amide → 1-Methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium amide | HCID 24532 | — |
| 반응물 | ethyl 1-methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxylate | HCID 15294535 | — |
| 생성물 | 1-Methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxamide | HCID 15294532 | 78% |
반응 단계
Prepared from ethyl 1-methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxylate and lithium amide as described in Example 18. After evaporation of excess ammonia, the residue is treated with ice water. The insoluble material is filtered and washed with water, then recrystallized from ethyl acetate-hexane. Yield 78%; mp 151°-154° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05424329 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-a14145a8404a40248665186c7668a3e0 |
| 출처 메모 | uspto-grants-1995_06 |