Lithium amide → 1-Methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxamide

HRID 21595

반응식

HRID 21595 반응식
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([O:11][CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:8][CH:9]=2)[C:4]([S:19][CH:20]([CH3:22])[CH3:21])=[C:3]1[C:23]([O:25]CC)=O.[NH2-:28].[Li+]>>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([O:11][CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:8][CH:9]=2)[C:4]([S:19][CH:20]([CH3:22])[CH3:21])=[C:3]1[C:23]([NH2:28])=[O:25]

참가 물질

3

반응물 2

HCID 24532Lithium amideHCID 15294535ethyl 1-methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxylate

생성물 1

HCID 152945321-Methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxamide수율 78%

실험 절차

Prepared from ethyl 1-methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxylate and lithium amide as described in Example 18. After evaporation of excess ammonia, the residue is treated with ice water. The insoluble material is filtered and washed with water, then recrystallized from ethyl acetate-hexane. Yield 78%; mp 151°-154° C.

후처리

  1. customAfter evaporation of excess ammonia
  2. additionthe residue is treated with ice water
  3. filtrationThe insoluble material is filtered
  4. washwashed with water
  5. customrecrystallized from ethyl acetate-hexane

출처 및 근거

ORD 기록
ord-a14145a8404a40248665186c7668a3e0
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05424329

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