Lithium amide → 5-Methoxy-1-methyl-3-[(1-methylethyl)thio]-1H-indole-2-carboxamide

HRID 21596

반응식

HRID 21596 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:12])[C:7]([C:13](OC)=[O:14])=[C:6]2[S:17][CH:18]([CH3:20])[CH3:19].[NH2-:21].[Li+]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:12])[C:7]([C:13]([NH2:21])=[O:14])=[C:6]2[S:17][CH:18]([CH3:20])[CH3:19]

참가 물질

3

반응물 2

HCID 24532Lithium amideHCID 15294536methyl 5-methoxy-1-methyl-3-[(1-methylethyl)thio]-1H-indole-2-carboxylate

생성물 1

HCID 152945335-Methoxy-1-methyl-3-[(1-methylethyl)thio]-1H-indole-2-carboxamide수율 68%

실험 절차

Prepared from methyl 5-methoxy-1-methyl-3-[(1-methylethyl)thio]-1H-indole-2-carboxylate and lithium amide as described in Example 23. Yield 68% after recrystallization from ethyl acetate-hexane; mp 122°-124° C.

후처리

  1. customYield 68% after recrystallization from ethyl acetate-hexane

출처 및 근거

ORD 기록
ord-a7f979b7f8b24b2c95f16e4a87726e4b
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05424329

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