Dimethylformamide → 5-Bromo-pyridine-2-carbonyl chloride

HRID 215961

반응식

HRID 215961 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.C(Cl)(=O)C([Cl:14])=O.CN(C)C=O>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([Cl:14])=[O:10])=[N:6][CH:7]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 6085445-Bromopyridine-2-carboxylic acid

생성물 1

HCID 190907715-Bromo-pyridine-2-carbonyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a mixture of 5-bromopyridine-2-carboxylic acid (2.5 g, 12 mmol) in methylene chloride (10.0 mL) was added oxalyl chloride (1.6 mL, 18 mmol), followed by N,N-dimethylformamide (0.020 mL, 0.26 mmol). After stirred at RT for 2 h, the mixture was evaporated under reduced pressure. The residue was the acid chloride which was used directly in next step reaction.

후처리

  1. customthe mixture was evaporated under reduced pressure
  2. customwas used directly in next step reaction

출처 및 근거

ORD 기록
ord-44363defda564c4996b698d619dbe1e3
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193207B2

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