Ethyl bromoacetate → Ethyl 2-(2-iminopyridin-1(2H)-yl)acetate hydrobromide

반응식

[Br:1][CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[NH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1>>[BrH:1].[CH2:6]([O:5][C:3](=[O:4])[CH2:2][N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]1=[NH:8])[CH3:7]

참가 물질

반응물 2

HCID 7748Ethyl bromoacetate

HCID 104392-Aminopyridine

생성물 1

HCID 68699194Ethyl 2-(2-iminopyridin-1(2H)-yl)acetate hydrobromide

실험 절차

To 39 mL (0.35 mol) of ethyl bromoacetate is added 9.4 g (0.1 mol) of 2-aminopyridine portionwise at 0° C. The resulting mixture is allowed to warm to room temperature and stirred at this temperature for 30 minutes. The precipitate is collected and washed with hexane to give the desired compound as light tan solid.

후처리

customThe precipitate is collected
washwashed with hexane

출처 및 근거

ORD 기록: ord-139322c54df1428e9f9697ab542f9be2
출처 데이터셋: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08193214B2

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