Lawesson's reagent → HCID 59176770, 화합물

HRID 215968노트

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HRID 215968 반응식
[C:1]1([CH2:11][CH:12]2[N:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]3=[N:14][C:13]2=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.COC1C=CC(P2(=S)SP(=S)(C3C=CC(OC)=CC=3)[S:31]2)=CC=1>C1(C)C=CC=CC=1.CO>[C:1]1([CH2:11][CH:12]2[N:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]3=[N:14][C:13]2=[S:31])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 2

HCID 87949Lawesson's reagentHCID 59176789HCID 59176789, 화합물

생성물 1

HCID 59176770HCID 59176770, 화합물

시약·촉매·용매 2

HCID 887Methanol용매HCID 1140Toluene용매

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온도
160 °C

실험 절차

A suspension of 200 mg (0.73 mmol) of 3-naphthalen-1-ylmethyl-imidazo[1,2-a]pyridin-2-one and 250 mg (0.62 mmol) of 2,4-bis-(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane 2,4-disulfide (Lawesson's reagent) in 20 mL of toluene is heated at 160° C. for 1 h under microwave condition. The resulting mixture is dissolved in methanol and absorbed on silica gel. The slurry is dried under reduced pressure and is purified by flash chromatography on silica gel. The compound is eluted 5˜10% methanol in dichloromethane solution to give the desired compound.

후처리

  1. customabsorbed on silica gel
  2. customThe slurry is dried under reduced pressure
  3. customis purified by flash chromatography on silica gel
  4. washThe compound is eluted 5˜10% methanol in dichloromethane solution

출처 및 근거

ORD 기록
ord-4afb7a9cdde94e8aafa4522f74e0360b
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193214B2

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