Imidazo[1,2-a]pyridin-2(3H)-one hydrobromide → 3-(4-Methyl-benzo[b]thiophen-3-ylmethylene)-imidazo[1,2-a]pyridin-2-one

HRID 215971노트

반응식

HRID 215971 반응식
Br.[N:2]1[C:3](=[O:11])[CH2:4][N:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=12.[CH3:12][C:13]1[C:21]2[C:20]([CH:22]=O)=[CH:19][S:18][C:17]=2[CH:16]=[CH:15][CH:14]=1>C(O)C>[CH3:12][C:13]1[C:21]2[C:20]([CH:22]=[C:4]3[N:5]4[CH:10]=[CH:9][CH:8]=[CH:7][C:6]4=[N:2][C:3]3=[O:11])=[CH:19][S:18][C:17]=2[CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 44121307Imidazo[1,2-a]pyridin-2(3H)-one hydrobromideHCID 579956704-Methyl-benzo[b]thiophene-3-carbaldehyde

생성물 1

HCID 686997973-(4-Methyl-benzo[b]thiophen-3-ylmethylene)-imidazo[1,2-a]pyridin-2-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 1.6 g (7.4 mmol) of imidazo[1,2-a]pyridin-2-one hydrobromide salt and 1.2 g (6.7 mmol) of 4-methyl-benzo[b]thiophene-3-carbaldehyde in 40 mL of ethanol is heated at reflux for 1 h and then cooled to room temperature. The precipitate is collected. The isolated solid is suspended in 40 mL of 2M potassium carbonate solution and the resulting mixture is stirred for 48 h at room temperature. The solid is collected and washed with water to give the desired compound.

후처리

  1. temperatureis heated
  2. temperatureat reflux for 1 h
  3. customThe precipitate is collected
  4. customThe solid is collected
  5. washwashed with water

출처 및 근거

ORD 기록
ord-c87e87eadcd744539f716a1f867b5e61
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193214B2

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