Dichloromethane → 5-Chloromethyl-4-(2-methoxy-ethyl)-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

반응식

[CH2:28]([Cl:29])[Cl:30].[CH3:1][O:2][CH2:3][CH2:4][c:5]1[n:6][c:7](-[c:14]2[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]2)[n:8][c:9]([CH3:13])[c:10]1[CH2:11][OH:12].[S:24]([Cl:25])([Cl:26])=[O:27]>>[CH3:1][O:2][CH2:3][CH2:4][c:5]1[n:6][c:7](-[c:14]2[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]2)[n:8][c:9]([CH3:13])[c:10]1[CH2:11][Cl:26]

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 24386Thionyl Chloride

HCID 21935907[4-(2-Methoxy-ethyl)-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-methanol

생성물 1

HCID 219357495-Chloromethyl-4-(2-methoxy-ethyl)-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

출처 및 근거

ORD 기록: ord-28d16c6c4b334a798420602071f56aa2
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

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