Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 216192생성일: 2026년 10월 24일
Cesium carbonate → 3-{6-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-2-methylsulfanyl-pyrimidin-4-yloxy}-benzoic acid ethyl ester
https://huagongshe.com/ko/reaction/216192
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | Ethyl 3-hydroxybenzoate | HCID 24522 | — |
| 반응물 | HCID 57636020 | HCID 57636020 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-{6-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-2-methylsulfanyl-pyrimidin-4-yloxy}-benzoic acid ethyl ester | HCID 69070693 | 83.5% |
반응 단계
A mixture of (6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine [250 mg, 0.74 mmol, Intermediate (31)], 3-hydroxy-benzoic acid ethyl ester (0.18 g, 1.1 mmol), and Cs2CO3 (0.48 g, 1.48 mmol) in DMF (4 mL) is heated to 90° C. for 15 h. The mixture is diluted with water, and extracted with EtOAc. The extracts are washed (water), dried (MgSO4), filtered, concentrated, and chromatographed (silica gel, 30% EtOAc in Heptane) to afford 3-{6-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-methylsulfanyl-pyrimidin-4-yloxy}-benzoic acid ethyl ester [0.29 g, 83%, Intermediate (71)]. LCMS: RT=3.7 minutes, MS: 470 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08193183B2 |
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| 출처 데이터셋 | uspto-grants-2012_06 |
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| ORD ID | ord-596feaa9dcfd49b8b8810981e291526a |
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| 출처 메모 | uspto-grants-2012_06 |
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