Water → (6-Chloro-2-methylsulfanyl-pyrimidin-4-yl)-[2-(2,4-dichloro-phenyl)-ethyl]-amine

참여 물질

역할	이름	HCID	투입량
반응물	Water	HCID 962	—
반응물	4,6-Dichloro-2-(methylthio)pyrimidine	HCID 80531	—
반응물	2,4-Dichlorophenethylamine	HCID 142938	—
반응물	Sodium Bicarbonate	HCID 516892	—
용매	Ethanol	HCID 702	—
생성물	(6-Chloro-2-methylsulfanyl-pyrimidin-4-yl)-[2-(2,4-dichloro-phenyl)-ethyl]-amine	HCID 80545555	72.3%

반응 조건

온도	85 °C

반응 단계

A mixture of 4,6-dichloro-2-methylsulfanyl-pyrimidine (2.66 g, 13.6 mmol), 2-(2,4-dichloro-phenyl)-ethylamine (2.26 mL, 15 mmol) and sodium bicarbonate (2.29 g, 27.2 mmol) in EtOH (35 mL) is heated to 85° C. for 1 hour and poured into water (100 mL). The solid precipitate is collected by filtration and dissolved in hot EtOH (75 mL). After cooling overnight the crystals that formed are collected by filtration and dried to afford (6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-[2-(2,4-dichloro-phenyl)-ethyl]-amine (3.43 g, 72%) as a solid.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08193183B2
출처 데이터셋	uspto-grants-2012_06
ORD ID	ord-b0de618506524590bcdeb5c36842485b
출처 메모	uspto-grants-2012_06