Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → N-(6-bromo-1,3-benzothiazol-2-yl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Benzothiazolamine, 6-bromo- | HCID 85149 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-(6-bromo-1,3-benzothiazol-2-yl)acetamide | HCID 3240669 | 74% |
반응 단계
To a solution of 2-amino-6-bromobenzothiazole (10 g, 43.65 mmol) and triethylamine (12.2 mL, 87.3 mmol) and N,N-dimethylaminopyridine (269 mg) in THF (100 mL) is added acetyl chloride (4.7 mL). After stirring for 17 hours water (100 mL) is added and the mixture is extracted twice with EtOAc (75 mL). The organic extracts are combined and dried over magnesium sulfate, filtered and concentrated to afford N-(6-bromo-benzothiazol-2-yl)-acetamide (8.79 g, 74%) as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08193183B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-31a0b31931a844cf9ba68387e50535f3 |
| 출처 메모 | uspto-grants-2012_06 |