Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,2-Diethoxyethylamine → 2,2-Dimethoxy-n-[(1-methyl-1h-benzimidazol-2-yl)methyl]ethanamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,2-Diethoxyethylamine | HCID 69524 | — |
| 반응물 | 1-methyl-1H-1,3-benzodiazole-2-carbaldehyde | HCID 762084 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2,2-Dimethoxy-n-[(1-methyl-1h-benzimidazol-2-yl)methyl]ethanamine | HCID 55218525 | 77.1% |
반응 단계
A solution of 1-methyl-2-formylbenzimidazole (1 g) in methanol (27 mL) and acetic acid (0.54 mL) was treated with aminoacetaldehyde diethylacetal (0.9 g, 1 equivalent) and NaCNBH3 (0.85 g, 2 equivalents) at 25° C., stirred for 1 hour. The mixture was partitioned between water and ethyl acetate. The organic layer was separated, washed sequentially with saturated NaHCO3 and brine, and concentrated. The residue was chromatographed on silica gel, eluting with 8% methanol/dichloromethane to give 1.2 g (64%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08193227B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-7e18d90a01dd45c1abefadd0378c5cef |
| 출처 메모 | uspto-grants-2012_06 |